Research Paper Volume 16, Issue 12 pp 10446—10461
Notoginsenoside R1 (NGR1) regulates the AGE-RAGE signaling pathway by inhibiting RUNX2 expression to accelerate ferroptosis in breast cancer cells
Figure 6. NGR1 induces ferroptosis in breast cancer cells by down-regulating RUNX2. (A) Changes in the concentration of MDA and Fe2+ in MDA-MB-23 and SK-BR-3 cells were detected after NGR1 treatment. (B, C) Changes in the expression of ACSL4, COX2, FIH1, GPX4, and NOX1 proteins were detected by Western blot in MDA-MB-231 and SK-BR-3 cells. (* P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001).