Research Paper Volume 16, Issue 12 pp 10446—10461
Notoginsenoside R1 (NGR1) regulates the AGE-RAGE signaling pathway by inhibiting RUNX2 expression to accelerate ferroptosis in breast cancer cells
Figure 5. NGR1 disrupts mitochondrial morphology in breast cancer cells by down-regulating RUNX2. The mitochondrial structure of breast cancer cells was observed by electron microscopy after transfection of siRNA in breast cancer MDA-MB-231 for 48 h, transfection of overexpression plasmid in SK-BR-3 for 48 h, and then NRG1 treatment for 48 h.