Research Paper Volume 16, Issue 12 pp 10424—10434
The beneficial effects of Rosuvastatin in inhibiting inflammation in sepsis
Figure 7. Rosuvastatin inhibited LPS-induced activation of NF-κB in RAW 264.7 macrophages. Cells were stimulated with LPS (10 ng/mL) with or without Rosuvastatin (10 and 20 μM) for 24 hours. (A) The levels of TLR4 and p-NF-κB p65 were measured by Western blot analysis; (B) NF-κB activity was measured using luciferase assays (n=8, ***, P<0.005 vs. control; #, ##, P<0.05, 0.01 vs. LPS group).