Research Paper Volume 16, Issue 11 pp 9309—9333
Dietary sucrose determines the regulatory activity of lithium on gene expression and lifespan in Drosophila melanogaster
Figure 6. Supplementing 1 mM LiCl to the 1% sucrose diet mimics half of the transcriptional response to 10% dietary sucrose. The Venn diagram shows overlaps of two comparisons: 1. the genes whose transcript levels were altered by increasing the sugar concentration from 1% to 10% (yellow circle, total: 1075) and 2. genes whose transcript levels were altered by supplementation of 1 mM LiCl to the 1% sucrose diet (blue circle, total: 844). Both comparisons share an overlap of 493 co-regulated genes differentially expressed in female flies in response to both, sucrose or lithium (FDR p-value ≤ 0.05). Suc., sucrose.