Research Paper Volume 16, Issue 11 pp 9309—9333

Dietary sucrose determines the regulatory activity of lithium on gene expression and lifespan in Drosophila melanogaster

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Figure 3. Lithium and dietary sucrose affect the body composition differently. Female flies were subjected to a 1%, 5% or 10% sucrose diet supplemented with 0, 0.1 or 1 mM LiCl and the body weight and body composition were examined after seven days of treatment. (A) Neither lithium, nor sucrose altered the body composition (one-way ANOVA, p ≤ 0.05). (B) Feeding 1% sucrose significantly lowered the TAG/protein ratio compared to a 5% or 10% sucrose diet (Dunnett’s T3 multiple comparisons test, ***p ≤ 0.001). (CE) Supplementing 1 mM LiCl to the 1 % sucrose diet slightly increased whole-body glucose level in the fly (one-way ANOVA, p = 0.07). Altering the sucrose content of the diet had no impact on any of the carbohydrate levels in the fly. Bars represent means ± SD. TAG, triacylglycerides; Suc., sucrose; BW, body weight. All data are reported as mean ± SD.