Research Paper Volume 16, Issue 11 pp 9309—9333

Figure 1. Lithium and dietary sucrose have a similar impact on the lifespan. Female w¹¹¹⁸ flies were subjected to life-long interventions receiving either the 1%, 5% or 10% sucrose diet supplemented with 0, 0.1 or 1 mM LiCl. (A) Increasing the dietary sucrose content to 10% extended the lifespan of the flies. (B) Supplementing 0.1 or 1 mM LiCl to the 1% sucrose diet extended the lifespan in a similar manner. (C) Supplemented to the 5% sucrose diet, only the dose of 1 mM LiCl significantly improved survival. (D) When added to the 10% sucrose diet, the positive impact of lithium on the lifespan further declined. Survival curves were compared using the Log-Rank Mantel-Cox test (p ≤ 0.05).