Figure 9 — Oxidative stress-induced EGR1 upregulation promotes NR4A3-mediated nucleus pulposus cells apoptosis in intervertebral disc degeneration

Research Paper|Volume 16, Issue 12|pp. 10216–10238

Oxidative stress-induced EGR1 upregulation promotes NR4A3-mediated nucleus pulposus cells apoptosis in intervertebral disc degeneration

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Figure 9.Diagram of the molecular mechanism by which EGR1 regulates NR4A3 in IVDD. By regulating NR4A3, EGR1 accelerates NPC apoptosis and impairs extracellular matrix anabolism, thereby promoting the progression of IVDD.