Research Paper Volume 16, Issue 12 pp 10216—10238
Oxidative stress-induced EGR1 upregulation promotes NR4A3-mediated nucleus pulposus cells apoptosis in intervertebral disc degeneration
Figure 9. Diagram of the molecular mechanism by which EGR1 regulates NR4A3 in IVDD. By regulating NR4A3, EGR1 accelerates NPC apoptosis and impairs extracellular matrix anabolism, thereby promoting the progression of IVDD.