Research Paper Volume 16, Issue 12 pp 10216—10238
Oxidative stress-induced EGR1 upregulation promotes NR4A3-mediated nucleus pulposus cells apoptosis in intervertebral disc degeneration
Figure 1. Abnormally expressed genes associated with IVDD identified using the GSE167199 and GSE15227 datasets. (A, B) Heatmap of all differentially expressed genes in degenerative intervertebral disc and nondegenerative intervertebral disc tissues from the GSE167199 and GSE15227 datasets. (C) Venn diagram showing the two selected transcription factors. (D) early growth response protein 1 (EGR1) was identified as a key gene. (E, F) EGR1 expression was analyzed by using the GSE167199 and GSE15227 datasets. (G) A volcano plot was created using RNA-seq data to show differentially expressed genes. (H) Bubble chart showing the KEGG pathway analysis of the RNA-seq data.