Research Paper Volume 16, Issue 11 pp 9933—9943
Ginsenoside Rg3 induces mesangial cells proliferation and attenuates apoptosis by miR-216a-5p/MAPK pathway in diabetic kidney disease
Figure 2. Rg3 induces proliferation and prevents apoptosis in HG-induced SV40 MES 13. HG-treated SV40 MES 13 were processed with 2, 4, and 8 μM Rg3. (A) Cell proliferation was monitored via CCK-8 in each group. (B) TUNEL analysis of cell apoptosis (Magnification, 200×). (C) Quantitative analysis of TUNEL results. (D) Western blot denoted the changes of cle-Caspase 3, cle-Caspase 8, Bcl2, and Bax expressions. ***P < 0.001 vs. control group; &&P < 0.01 and &&&P < 0.001 vs. HG group.