Research Paper Volume 16, Issue 11 pp 9859—9875

Tsc22d3 promotes morphine tolerance in mice through the GPX4 ferroptosis pathway

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Figure 4. Construction and analysis of protein-protein interaction (PPI) networks. (A) Construct the PPI network of DEGs using STRING online database and utilize Cytoscape software for analysis. (B) MCC was used to identify the central gene. (C) MNC was used to identify the central gene. (D) DMNC was used to identify the central gene. (E) EPC was used to identify the central gene. (F) EcCentricity was used to identify the central gene. (G) Core genes (Tsc22d3, Itga6, Ermn, Sult1a1) were obtained by merging using Venn diagrams.