Targeting cGAS-STING signaling protects retinal ganglion cells from DNA damage-induced cell loss and promotes visual recovery in glaucoma

Qiuli Zhang; Yinghuan Xiong; Ruizhuang Li; Xiuqin Wang; Xu Lin; Ya&#x2019;ni Tong

doi:doi:10.18632/aging.205900

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Research Paper Volume 16, Issue 11 pp 9813—9823

Targeting cGAS-STING signaling protects retinal ganglion cells from DNA damage-induced cell loss and promotes visual recovery in glaucoma

Figure 6. Role of cGAS-STING on the inflammatory response and visual function. (A) The role of STING inhibitor C176 on IOP of HS-induced glaucoma mice. (B) The role of C176 on the visual acuity of HS-induced glaucoma mice. (C) The role of C176 on the contrast threshold of HS-induced glaucoma mice. (D) The role of C176 on pro-inflammatory molecule expression. *p<0.05.