Research Paper Volume 16, Issue 11 pp 9692—9708

Figure 1. Pan-cancer SETD2 expression and its impact on survival and migration in melanoma. (A) Pan-cancer expression of SETD2 between tumor tissues and peri-tumor samples from TCGA, TARGET, and GTEx database. (B) Kaplan-Meier overall survival of SETD2 in melanoma from TCGA database., the best cut off value of SETD2 was taken. (C, D) Wound-healing assay compared the cell migration of A375^SETD2ko and A375^WT cells for 48h. Wound healing rate = (S_0h-S_48h)/S_0h%. (E) CCK-8 testing the proliferation inhibition of A375^SETD2ko and A375^WT. (F, G) Tumor volume of A375^SETD2ko and A375^WT cells beard by nude mice. *p < 0.05, **p < 0.01, ** *p < 0.001, the asterisk represents the degree of importance (*p). The significance of the two groups of samples passed the t-tests.