Research Paper Volume 16, Issue 11 pp 9569—9583
Attenuating bone loss in osteoporosis: the potential of corylin (CL) as a therapeutic agent
Figure 3. Inhibition of RANKL-induced NFATc1 and c-fos transcription and downstream related genes by CL. BMMs were treated with CL in osteoclast induction medium for 3 days. (A) The analysis of the relative mRNA levels of NFATc1, c-fos, RANK, Cathepsin K, MMP9, and TRAP. (B) The protein band image of NFATc1 and c-fos. (C) The expression quantifying of NFATc1 and c-fos. (D) The protein band image of Cathepsin K and MMP9. (E) The expression quantifying of Cathepsin K and MMP9. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.