Research Paper Volume 16, Issue 11 pp 9558—9568

Figure 6. Treatment with orexin-A attenuated IL-1β-induced reduction of SIRT3. (A, B) Cells were stimulated with IL-1β (5, 10 ng/ml). mRNA and protein levels of SIRT3 were measured. (C, D) Cells were stimulated with IL-1β (10 ng/ml) with or without orexin-A (5 and 10 μM). mRNA and protein levels of SIRT3 were measured (^{#, ##}P < 0.05, 0.01 vs. vehicle group; ^{^, ^^}P < 0.05, 0.01 vs. IL-1β group, n = 5).