Research Paper Volume 16, Issue 11 pp 9558—9568

The protective effects of orexin-A in alleviating cell senescence against interleukin-1β (IL-1β) in chondrocytes

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Figure 3. Treatment with orexin-A ameliorated IL-1β-induced reduction in telomerase activity. (A) Cells were stimulated with IL-1β (5, 10 ng/ml) for 14 days. Telomerase activity was measured; (B) Cells were stimulated with IL-1β (10 ng/ml) with or without orexin-A (5 and 10 μM) for 14 days. Telomerase activity was measured (#, ##P < 0.05, 0.01 vs. vehicle group; ^, ^^P < 0.05, 0.01 vs. IL-1β group, n = 5).