Research Paper Volume 16, Issue 11 pp 9558—9568
The protective effects of orexin-A in alleviating cell senescence against interleukin-1β (IL-1β) in chondrocytes
Figure 1. Exposure to IL-1β reduced the expression of orexin-2 receptor (orexin-2R) in TC-28a2 chondrocytes in a dose-dependent manner. Cells were stimulated with IL-1β (5, 10 ng/ml) for 24 hours. (A) mRNA levels of orexin-2R; (B) Protein levels of orexin-2R (#, ##P < 0.05, 0.01 vs. vehicle group, n = 6).