Research Paper Volume 16, Issue 10 pp 9264—9279
Bufotalin enhances apoptosis and TMZ chemosensitivity of glioblastoma cells by promoting mitochondrial dysfunction via AKT signaling pathway
Figure 3. Bufotalin attenuated the EMT process of GBM cells. (A–D) The effect of bufotalin on U87 and U251 migration was assessed by wound healing assay at 24 h and 48 h. (E–H) The effect of bufotalin on U87 and U251 invasion was assessed by Transwell assay. (I, J) The expression levels of E-cadherin and Vimentin were analyzed by western blot. The data are representatives of three independent experiments and are presented as the mean ± SD. Significant differences compared with the control are indicated by *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.