Research Paper Volume 16, Issue 10 pp 9264—9279

Bufotalin enhances apoptosis and TMZ chemosensitivity of glioblastoma cells by promoting mitochondrial dysfunction via AKT signaling pathway

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Figure 2. Functional enrichment analysis of DEGs after treatment of bufotalin according to RNA-seq in U87 cells. (A) volcano plot. (B) GO enrichment analysis of downregulated DEGs. (C) KEGG enrichment analysis of upregulated DEGs. (D, E) GSEA enrichment analysis between the control group and the bufotalin group.