Research Paper Volume 16, Issue 10 pp 9264—9279
Bufotalin enhances apoptosis and TMZ chemosensitivity of glioblastoma cells by promoting mitochondrial dysfunction via AKT signaling pathway
Figure 1. Bufotalin inhibits cell proliferation in GBM cells. (A) The molecular structure of bufotalin. (B, C) CCK-8 assay was used to determine the cell viability of U87 and U251 cells treated with bufotalin for 24 h and 48 h. (D–G) Bufotalin suppressed U87 and U251 cells’ colony formation. The data are representative of three independent experiments and are presented as the mean ± SD. Significant differences compared with the control are indicated by *p < 0.05, **p < 0.01, and ***p < 0.001.