Research Paper Volume 16, Issue 11 pp 9547—9557
Neratinib stimulates senescence of mammary cancer cells by reducing the levels of SIRT1
Figure 6. Neratinib decreased the gene levels of hTERT but increased the gene levels of TERF2 in AU565 cells. Cells were stimulated with Neratinib (1, 2.5, 5 μM) for 14 days. (A) Gene levels of hTERT; (B) Gene levels of TERF2 (^, ^^, ^^^, P<0.05, 0.01, 0.005 vs. vehicle group).