Research Paper Volume 16, Issue 11 pp 9547—9557
Neratinib stimulates senescence of mammary cancer cells by reducing the levels of SIRT1
Figure 5. Neratinib stimulated cellular senescence in AU565 cells. Cells were stimulated with Neratinib (1, 2.5, 5 μM) for 14 days. The SA-β-Gal assay was used to assess cellular senescence (^, ^^, ^^^, P<0.05, 0.01, 0.005 vs. vehicle group).