Research Paper Volume 16, Issue 11 pp 9547—9557
Neratinib stimulates senescence of mammary cancer cells by reducing the levels of SIRT1
Figure 4. Neratinib reduced the levels of telomerase activity in AU565 cells. (A) Cells were stimulated with Neratinib (1, 2.5, 5 μM) for 7 days. The telomerase activity was assayed; (B) Cells were stimulated with Neratinib (1, 2.5, 5 μM) for 14 days. The telomerase activity was assayed (^, ^^, ^^^, P<0.05, 0.01, 0.005 vs. vehicle group).