Research Paper Volume 16, Issue 11 pp 9547—9557
Neratinib stimulates senescence of mammary cancer cells by reducing the levels of SIRT1
Figure 3. The effects of Neratinib in DNA damage in AU565 cells. Cells were stimulated with Neratinib (1, 2.5, 5 μM) for 72 hours. (A) The levels of 8-OHdG as measured by a commercial kit; (B) The levels of γH2AX (^, ^^, ^^^, P<0.05, 0.01, 0.005 vs. vehicle group).