Research Paper Volume 16, Issue 11 pp 9547—9557
Neratinib stimulates senescence of mammary cancer cells by reducing the levels of SIRT1
Figure 1. Neratinib induced cytotoxicity in mammary cancer AU565 cells. (A) Molecular structure of Neratinib; (B) Cells were stimulated with 0.5, 1, 2.5, 5 μM Neratinib for 36 hours. LDH release was measured using a commercial kit; (C) Cells were stimulated with 0.5, 1, 2.5, and 5 μM Neratinib for 72 hours. LDH release was measured using a commercial kit (^, ^^, ^^^, P<0.05, 0.01, 0.005 vs. vehicle group).