Research Paper Volume 16, Issue 11 pp 9518—9546
Glutathione metabolism-related gene signature predicts prognosis and treatment response in low-grade glioma
Figure 1. Identification of two distinct clusters in low-grade glioma (LGG) patients using consensus clustering. (A) The protein-protein interaction (PPI) network of GMRGs. (B) Kaplan-Meier (K-M) survival analysis based on glutathione metabolism scores. (C) Consensus clustering divides all The Cancer Genome Atlas (TCGA)-LGG patient samples into two clusters. (D) PCA analysis shows that the two GMRGs-related clusters are distinctly separated. (E) Glutathione metabolism differs between the two clusters. (F) Glutathione metabolism related genes (GMRGs) expression levels in the two clusters. (G) Survival differences between the two clusters in OS, disease-specific survival (DSS), progression-free survival (PFS), and disease-free survival (DFS).