Research Paper Volume 16, Issue 10 pp 9228—9250
Leveraging pQTL-based Mendelian randomization to identify new treatment prospects for primary biliary cholangitis and primary sclerosing cholangitis
Figure 6. Validation of external dataset and IHC experiment. (A) Expression levels of HSPB1 and ITIH5 between PBC and control groups in GSE119600 dataset; (B) Expression levels of FCGR2A, FCGR3B, and RNASET2 between PSC and control groups in GSE119600 dataset; (C) IHC staining of HSPB1 encoding proteins in liver samples of PBC patients and normal individuals; (D) IHC staining of LEFTY2 encoding proteins in liver samples of PBC patients and normal individuals (E) IHC staining of FCGR3B encoding proteins in liver samples of PSC patients and normal individuals. Abbreviations: IHC: immunohistochemistry; PBC: primary biliary cholangitis; PSC: primary sclerosing cholangitis. *p-value < 0.05, **p-value < 0.01, ***p-value < 0.001.