Research Paper Volume 16, Issue 10 pp 8417—8445

Figure 8. Significant proteomic changes in the serum of wild type and Wrn^Δhel/Δhel females at four and ten months of age. (A) Hierarchical clustering of label-free quantification (LFQ) intensities of 35 serum proteins that differed significantly in at least one of the comparisons between the various female groups with a two-fold change, a p-value < 0.05, and a |Z-score| >1.96. Numbers of proteins and intensity profiles are indicated for each cluster trend plots. (B) Gene ontology analysis of Cluster 2 and Cluster 5 that exhibited significant altered biological pathways between the different groups of females. (C) Two-way ANOVA showing the number of proteins that significantly changed based on the age and/or the genotype of the females in Cluster 2 and Cluster 5.