Research Paper Volume 16, Issue 10 pp 8417—8445

Figure 4. Impact of sexual dimorphism on the liver proteome profiles of wild type and Wrn^Δhel/Δhel mice at four and ten months of age. (A) Principal component analysis (PCA) graph of all wild type and Wrn^Δhel/Δhel mice at four and ten months of age. (B) Heatmap depicting the Z-score value of log base 2 of liver protein (rows) between individual (columns) wild type and Wrn^Δhel/Δhel that significantly separated females and males. (C) Venn diagram presenting the number of quantified proteins that were unchanged or altered between the different groups of females. (D) Venn diagram presenting the number of quantified proteins that were unchanged or altered between the different groups of males.