Research Paper Volume 16, Issue 10 pp 8417—8445
Integrated liver and serum proteomics uncover sexual dimorphism and alteration of several immune response proteins in an aging Werner syndrome mouse model
Figure 3. Histological features of the liver, body weight, food intake, and water consumption of wild type and WrnΔhel/Δhel mice at four and ten months of age. (A) Number of macrovesicles. (B) Percentage of hepatocytes with enlarged microvesicles. (C) Number of inflammatory infiltrates. (D) Body weight. (E) Food intake. (F) Water consumption. (A–D) N = four to six mice per group. (E, F) N = eight to twelve mice per group. All the graphs represent the mean of each group. Bars represent the SEM. Two-way ANOVA p-values for age, genotype, and the interaction (age x genotype) are indicated on top of each graph. (Two-way ANOVA followed by Tukey’s multiple comparisons test p-value < 0.05 are indicated by * in the graphs for each comparison).