Research Paper Volume 16, Issue 10 pp 8417—8445

Integrated liver and serum proteomics uncover sexual dimorphism and alteration of several immune response proteins in an aging Werner syndrome mouse model

class="figure-viewer-img"

Figure 11. Serum levels of six cytokines significantly altered in the various wild type and WrnΔhel/Δhel female and male groups. (A) IL-1ß. (B) IL-5. (C) IL-12 (p40 subunit). (D) Eotaxin. (E) KC. (F) TNF-α. All the graphs represent the mean of each group. Bars represent the SEM. Two-way ANOVA p-values for age, genotype, and the interaction (age x genotype) are indicated on top of each graph. Two-way ANOVA followed by Tukey’s multiple comparisons test p-value < 0.05 are indicated by * in the graphs for each comparison. (N = 9–12 males or females per group).