Research Paper Volume 16, Issue 10 pp 8417—8445
Integrated liver and serum proteomics uncover sexual dimorphism and alteration of several immune response proteins in an aging Werner syndrome mouse model
Figure 10. Box plots of protein LFQ intensities significantly altered between wild type and WrnΔhel/Δhel mice at four and ten months of age in both serum and liver samples. (A) Box plots of serum and liver proteins significantly altered in females. (B) Box plots of serum and liver proteins significantly altered in males. LFQ intensities are presented as log base 2 values. Significant differences between groups are indicated in each box plot. Proteins were considered significant between the indicated groups with a two-fold change, a limma p-value < 0.05, and a |Z-score| >1.96.