Research Paper Volume 16, Issue 10 pp 8417—8445
Integrated liver and serum proteomics uncover sexual dimorphism and alteration of several immune response proteins in an aging Werner syndrome mouse model
Figure 1. Experimental design of the study. Four males and four females at four and ten months of age were euthanized to collect the serum and the whole liver. For each animal, a part of the liver was used for histology analysis and another part was used for protein extraction and mass spectrometry analysis. The whole serum was depleted of abundant proteins before mass spectrometry analyses.