← Back
Research Paper Volume 16, Issue 10 pp 9216—9227

The protective effects of Chromofungin in oligomeric amyloid β42 (Aβ42)-induced toxicity in neurons in Alzheimer’s disease

class="figure-viewer-img"

Figure 7. Overexpression of COX-2 impaired the beneficial function of Chromofungin against oligomeric Aβ42-induced cellular senescence in M17 neuronal cells. M17 cells were transduced with Ad-COX-2 and incubated with Chromofungin (1 mM) with oligomeric Aβ42 (5 μM). (A) mRNA expression of hTERT and TERF2; (B) Telomerase activity; (C) The mRNA levels of p21; (D) Cellular senescence was examined using SA-β-gal staining at day 14 (n = 6, **P < 0.01 vs. vehicle group; ††P < 0.05, 0.01 vs. Aβ42 group; ※, ※※P < 0.05, 0.01 vs. Aβ42+Chromofungin group).