Figure 5. The PI3K/AKT pathway activation after DKK2 knockdown/overexpression. (A, B) After overexpressing DKK2 in SCC15 cells, the activation of the PI3K/AKT pathway was detected by Western blot assay. (C, D) After knocking down DKK2 in CAL27 cells, the activation of the PI3K/AKT pathway was detected by Western blot assay. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.