Research Paper Volume 16, Issue 10 pp 9072—9105

Figure 3. Analysis of differential expression between AD patients and controls. (A, B) Box plots of CMA-related genes differentially expressed in GSE15222 and GSE5281, distinguishing the AD group from the control group. Both GFAP and LAMP2 showed a trend of upregulation in (A) and (B), and HSP90AB1 shows a different trend. (C) Box-plot of CMA-related genes differentially expressed in GSE1297, shown according to control, incipient dementia, moderate dementia, and severe dementia. GFAP expression gradually increased with increasing dementia in (C). Additionally, the T-test was utilized to verify the significance of gene expression, with detailed results available in Supplementary File 6.