Research Paper Volume 16, Issue 10 pp 8965—8979
CRYAB suppresses ferroptosis and promotes osteogenic differentiation of human bone marrow stem cells via binding and stabilizing FTH1
Figure 7. FTH1 was decreased in osteoporosis. (A) mRNA expression level of FTH1 in osteoporosis samples was detected using qRT-PCR. (B) Schematic illustration of the current study: downregulation of CRYAB boosted FTH1 degradation and increased cellular Fe and ROS levels, and finally improved the ferroptosis and lessened the osteogenic differentiation of BMSCs. ****: p < 0.0001.