Research Paper Volume 16, Issue 10 pp 8880—8897
PDIA3 driven STAT3/PD-1 signaling promotes M2 TAM polarization and aggravates colorectal cancer progression
Figure 8. PDIA3 is pivotal in accentuating colorectal cancer proliferation and metastasis, orchestrated through strategic regulation of the STAT3/PD-1 signaling axis and the concurrent promotion of tumor-associated macrophage M2 polarization. Under the condition of co-culture of tumor-associated macrophages and SW480 cells, PDIA3 can promote the expression of PD-1 by enhancing the phosphorylation of STAT3, and PD-1 is then secreted extracellularly. PD-1 acts on the PD-L1 receptor of SW480 cells, thereby promoting the expression of arg1, IL-6, and XBP-1, and inhibiting the secretion of cathepsin L, cathepsin K, and IL-6. This further promotes the migration, invasion, and proliferation abilities of SW480 cells.