Research Paper Volume 16, Issue 10 pp 8880—8897
PDIA3 driven STAT3/PD-1 signaling promotes M2 TAM polarization and aggravates colorectal cancer progression
Figure 3. In vivo experiments demonstrate that PDIA3 significantly contributes to oncogenesis. (A) SW480 cells, genetically modified to either overexpress or suppress PDIA3, were subcutaneously injected into nude mice to create CRC tumor models. Statistical evaluation via T-test,* *P < 0.01 versus normative control. (B) RT-qPCR detection of PDIA3 mRNA in CRC tumors. Statistical evaluation via T-test,* *P < 0.01 versus normative control. (C) Western blot detection of PDIA3 protein in CRC tumors. Statistical evaluation via T-test,* *P < 0.01 versus normative control.