Research Paper Volume 16, Issue 10 pp 8880—8897

Figure 1. Bioinformatic analyses suggest that PDIA3 exhibits notably elevated expression in colorectal cancer (CRC) and demonstrates significant associative upregulation with STAT3, CD274, and monocyte/macrophage levels. (A) Widespread expression of PDIA3 across multiple cancer types. Statistical comparison via T-test, P<0.001. (B) Differential expression of PDIA3 within colorectal adenocarcinoma (COAD). Statistical comparison via T-test, P<0.05. (C) Evaluative correlation between PDIA3 and STAT3 expressions in COAD. Correlation coefficient (R) = 0.78, P=0.85E-98. (D) Evaluative correlation between PDIA3 and CD274 expressions in COAD. Correlation coefficient (R) = 0.43, P=2.71E-22. (E) Analysis of the correlation between PDIA3 and macrophages in pan cancer. Statistical comparison via T-test, P<0.05. (F) Survival analysis depicting Overall Survival (OS) (Log-rank P=0.97) and Disease-Free Survival (DFS) (Log-rank P=0.35) as influenced by PDIA3 expression in COAD.