Figure 2. mRNA levels of serine racemase, as determined by RT-PCR analysis, decreased with age in select subregions of the male Fisher 344 rat brain. Bars demonstrating the quantitative fold change in SR mRNA in (A) medial prefrontal cortex (mPFC), (B) CA1 subfield of the hippocampus, (C) CA3 subfield of the hippocampus, (D) No changes in dentate (DG) subfield of the hippocampus were observed. Asterisks for p-values indicate significance (*p<0.05, **p<0.005, ***p<0.0001).