Research Paper Volume 16, Issue 10 pp 8822—8842
Inflammation-based lung adenocarcinoma molecular subtype identification and construction of an inflammation-related signature with bulk and single-cell RNA-seq data
Figure 4. Identification of the predictive hub genes for the construction of a risk signature. (A) Forrest plot of prognosis-related inflammation genes identified by univariate Cox regression analysis. (B) The trajectory of each independent variable with lambda. (C) Plot of the generated coefficient distributions for the logarithmic (lambda) series for parameter selection. (D) Multivariate Cox coefficients for each gene in the risk signature. (E–H) Kaplan–Meier and ROC curves of the risk model constructed using the data of 15 genes from TCGA, GSE3141, GSE37745, and GSE68465 cohorts.