Research Paper Volume 16, Issue 10 pp 8667—8686
Identification of a novel matrix metalloproteinases-related prognostic signature in hepatocellular carcinoma
Figure 4. Construction and validation of the MMPs-related prognostic signature. (A) LASSO regression with tenfold cross-validation found nine prognostic genes using the minimum λ. (B) LASSO coefficient profiles of nine prognostic genes of HCC. (C, D) Heatmap, PCA plot, distribution, survival status, Kaplan-Meier curves for OS and ROC curves demonstrated the predictive efficiency of the risk score in entire, training, and testing cohorts. (E) Validation of the MMPs-related prognostic signature in the training cohort of TCGA-LIHC. (F) The validation of the MMPs-related prognostic signature in the ICGC-LIRI-JP cohort. (G) Univariate analysis of risk score and clinicopathological characteristics in the TCGA-LIHC training and testing cohorts. (H) Multivariate analysis of risk score and clinicopathological characteristics in the TCGA-LIHC training and testing cohorts.