Research Paper Volume 16, Issue 10 pp 8657—8666
Gastrodin ameliorates neuroinflammation in Alzheimer’s disease mice by inhibiting NF-κB signaling activation via PPARγ stimulation
Figure 7. GAS inhibited the microglial inflammation. (A) CCK-8 (n = 3), GAS could inhibit amyloid-induced microglial damage and improve the survival rate. (B–D) ELISA (n = 3), amyloid could induce the expressions of inflammatory cytokines, while GAS could inhibit such changes and lower the cytokine levels in the medium. (E–F) Relative protein expressions (n = 3), GAS could elevate the p-PPARγ level, lower the p-P50 and p-P65 expressions, and inhibit the NF-κB signaling. *P < 0.05 vs. Control; #P < 0.05 vs. Aβ1-42.