Research Paper Volume 16, Issue 10 pp 8657—8666
Gastrodin ameliorates neuroinflammation in Alzheimer’s disease mice by inhibiting NF-κB signaling activation via PPARγ stimulation
Figure 5. PPARγ silencing could antagonize the effect of GAS. (A, B) Morris (n = 10), Si-PPARγ group exhibited longer escape latency and more platform crossings compared to the AD group, while GAS+Si-PPARγ could not improve the mouse behaviors, showing insignificant differences from the Si-PPARγ group. (C–F) Eight-arm maze (n = 10), the latency, total movement distance and open-arms time were all longer in the Si-PPARγ and GAS+Si-PPARγ groups than in the AD group, albeit absence of inter-group differences. *P < 0.05 vs. AD.