Research Paper Volume 16, Issue 10 pp 8657—8666
Gastrodin ameliorates neuroinflammation in Alzheimer’s disease mice by inhibiting NF-κB signaling activation via PPARγ stimulation
Figure 4. Effects of GAS on the AD mice pathology. (A–C) ELISA (n = 10), upregulations of inflammatory cytokines were noted in AD mice, which were significantly higher than those in Control, while GAS could dose-dependently reduce these cytokine expressions. (D, E) Relative protein expressions (n = 5), in the AD group, PPARγ activation was inhibited, p-PPARγ was downregulated, while NF-κB was activated. GAS could activate PPARγ to inhibit the NF-κB signaling and reduce the expressions of p-P50 and p-P65. *P < 0.05 vs. Control; #P < 0.05 vs. AD.