Research Paper Volume 16, Issue 10 pp 8645—8656

Figure 3. Mangiferin protects neurons from LPS injury. LPS-exposed neurons are incubated with 20 μmol/L or 40 μmol/L of mangiferin for 24 h or 48 h and then analyzed with the CCK8 assay. LPS treatment significantly affected cell viability (66.41% in 24 h, 61.07% in 48 h, ^***P < 0.001 compared to the PBS control group), while 20 μmol/L (76.50% in 24 h, 79.91% in 48 h, ^***P < 0.001) and 40 μmol/L (81.54% in 24 h, 88.02% in 48 h, ^***P < 0.001) of mangiferin countered the LPS-induced phenotype. Data are presented as mean ± SD. One-way ANOVA is used for statistical analysis; ^***P < 0.001.