Research Paper Volume 16, Issue 10 pp 8630—8644
Neferine mitigates angiotensin II-induced atrial fibrillation and fibrosis via upregulation of Nrf2/HO-1 and inhibition of TGF-β/p-Smad2/3 pathways
Figure 1. Neferine inhibited Ang II-induced AF and atrial dilation in mice. (A) 8-week-old mice were infused with saline or Ang II (2000ng/kg/min) and received vehicle or neferine (20 mg/kg) each day for 4 weeks (n = 10 samples per group). (B, C) Electrocardiogram of the occurrence of AF stimulated by burst pacing and the incidence of AF in each treatment group (n = 10). (D) Average AF duration induced by burst pacing (n = 10). (E) Echocardiography showed representative images of two-dimensional M-mode for the measurement of left atrium dimension (LAD, mm). Data are presented as mean ± SEM, and n represents the number of samples per group. *P < 0.05 for the difference compared with the Saline group; #P < 0.05 for the difference compared with the Ang II group.