Senolytic effects of exercise in human muscles require acute inflammation

Wei-Horng Jean; Yin-Chou Lin; Pei-Yao Ang; Kazushige Goto; Chao-An Lin; Luthfia Dewi; Yu-Chieh Liao; Chih-Yang Huang; Chia-Hua Kuo

doi:doi:10.18632/aging.205827

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Research Paper Volume 16, Issue 10 pp 8599—8610

Senolytic effects of exercise in human muscles require acute inflammation

Figure 1. Effect of ibuprofen on p16^INK4a expression in human skeletal muscle after HIIE. Decreased p16^INK4a mRNA after HIIE was attenuated by ibuprofen administration (A). A wide individual variation of the exercise response was observed for both placebo (B) and ibuprofen (C) trials. ^†Denotes significant difference against placebo, p < 0.05; ^*denotes significant difference against Pre, p < 0.05. Abbreviation: HIIE: high intensity interval exercise.