Research Paper Volume 16, Issue 10 pp 8585—8598

MiR-371-5p regulates trophoblast cell proliferation, migration, and invasion by directly targeting ZNF516

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Figure 1. MiR-371-5p expression is decreased in patients with preeclampsia. (A, B) Volcano plot and heatmap showing DEGs in GSE15789 (n = 215, P < 0.05, red arrows, miR-371-5p). (C) The GSE15789 and GSE84260 datasets’ upregulated (left panel) and downregulated genes (right panel) are shown in Venn diagrams. (D) The present study involved the utilization of RT-PCR in analyzing the expression levels of hsa-miR-193b, hsa-miR-210, hsa-miR-193a-3p, hsa-miR-371-5p, and hsa-miR-125a-3p in the placenta. Control, n = 71; EOPE, n = 34; and LOPE, n = 55. ****P < 0.0001.