Research Paper Volume 16, Issue 10 pp 8511—8523
LncRNA SH3BP5-AS1 promotes hepatocellular carcinoma progression by sponging miR-6838-5p and activation of PTPN4
Figure 4. The SH3BP5-AS1/miR-6838-5p/PTPN4 axis regulated glycolysis in HCC. (A, B) By sponging miR-6838-5p, SH3BP5-AS1 activated PTPN4. (C–E) Ectogenic miR-6838-5p lessened the effect of SH3BP5-AS1 on glucose absorption and lactate production. (F–H) Knockdown of PTPN4 reversed the increasement in HCC cells’ glycolysis brought on by the suppression of miR-6838-5p. (I–K) Using qRT-PCR experiment, the expression levels of PDK1, PFK1, and PKM2 in HCC cells were investigated.